WR DeAndre Hopkins is questionable with an injured ankle. LG Peter Skoronski was ruled out Saturday after being added to the injury report Friday with an illness. The Titans will be without two starters in the defensive secondary with S Amani Hooker in the concussion protocol and CB Kristian Fulton dealing with an injured hamstring. OLB Joey Bosa is questionable with a hamstring injury. Ekeler is sidelined due to an ankle sprain and Kendricks has a hamstring issue. KEY INJURIES: Ekeler and LB Eric Kendricks have been ruled out after not practicing all week. Ekeler led a Chargers’ backfield that piled up a league-best 234 yards in the opener and scored three touchdowns. Tennessee had the NFL’s stingiest defense against the run last season and gave up just 69 yards in its opener. KEY MATCHUP: Titans defense against the Chargers rushing attack. He also overthrew a couple of wide-open receivers and underthrew a pass into double coverage for an interception. He had a career-low 28.8 passer rating in the opening loss in New Orleans with three interceptions and no touchdown passes. TITANS PLAYER TO WATCH: QB Ryan Tannehill is coming off his worst game since perhaps his rookie season. Kelley had 91 yards rushing on 16 carries in Week 1. The fourth-year back will get the start with Austin Ekeler sidelined. TURNOVER DIFFERENTIAL: Chargers plus-2 Titans minus-1.ĬHARGERS PLAYER TO WATCH: RB Joshua Kelley. TITANS DEFENSE: OVERALL (23), RUSH (5), PASS (26), SCORING (t-8). LAST WEEK: Chargers lost to Dolphins 36-34 Titans lost to Saints 16-15.ĬHARGERS OFFENSE: OVERALL (2), RUSH (1), PASS (13), SCORING (4).ĬHARGERS DEFENSE: OVERALL (30), RUSH (6), PASS (30), SCORING (t-28).

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